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FLASH GENE
Symbol CD70 contributors: mct - updated : 18-05-2009
HGNC name CD70 molecule
HGNC id 11937
PROTEIN
PHYSICAL PROPERTIES Hydrophilic Hydrophobic
STRUCTURE
motifs/domains
  • a 20 AA hydrophilic N-terminal domain
  • 18-amino acid hydrophobic region that presumably functions as a transmembrane anchor
  • an extracellular C-terminal domain
  • two potential N-linked glycosylation sites
  • conjugated GlycoP
    mono polymer homomer , trimer
    HOMOLOGY
    Homologene
    FAMILY
  • tumor necrosis factor family
  • CATEGORY antigen , signaling cytokine
    SUBCELLULAR LOCALIZATION     plasma membrane
    text single pass type II membrane protein
    basic FUNCTION
  • acting as a ligand for TNFRSF27/CD27
  • inducing proliferation of costimulated T cells, enhancing the generation of cytolytic T cells, and contributing to T cell activation (Goodwin 1993)
  • playing a role in regulating B-cell activation, cytotoxic function of natural killer cells and immunoglobulin synthesis
  • surface antigen on activated but not on resting, T and B lymphocytes
  • is critical for stimulation of an effective cytotoxic T cell response against B cell precursor acute lymphoblastic leukemia (Glouchkova 2009)
  • promotes lymphocyte apoptosis through interaction with its receptor and SIVA, contributing to the failure of RCC patients to develop an effective lymphocyte mediated ntitumor response (Diegmann 2006)
  • CD70 and ITGAL facilitate the survival of T, B lymphocytes and indirectly enhance the destruction of platelets in immune thrombocytopenia
  • CELLULAR PROCESS cell life, proliferation/growth
    cell communication
    PHYSIOLOGICAL PROCESS immunity/defense
    text cell-cell signaling
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to CD27
  • cell & other
    REGULATION
    induced by PGE2, facilitating T-cell/T-cell interaction that warrant long-lasting costimulation (Krause 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    lower expression in naive B cells from CIVD patients (Groth 2002)
    tumoral     --over  
    overexpressed in systemic lupus erythematosus T cells, increasing B cell costimulation and subsequent immunoglobulin overproduction may contribute to drug-induced and idiopathic lupus (Oelke 2004)
    tumoral     --over  
    overexpressed in rena cell carcinoma (Diegmann 2006)
    tumoral     --over  
    up-regulated more than 1,000 fold in various HTLV1-carrying T cell lines (Baba 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    bloodcoagulation 
    blockade of CD70 or ITGAL are promising therapeutic approaches for immune thrombocytopenia
    cancerhemopathy 
    potential target for effective antibody therapy against adult T-cell leukemia
    cancerurinary 
    potential target antigen for toxin-conjugated therapeutic antibody treatment of renal cell carcinoma
    ANIMAL & CELL MODELS