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FLASH GENE
Symbol RAB5B contributors: mct/ - updated : 06-02-2019
HGNC name RAB5B, member RAS oncogene family
HGNC id 9784
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Rab5b
Homologene
FAMILY
  • small GTPase superfamily
  • Rab family
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • GTPase involved in endocytosis
  • involved in vesicular trafficking at the plasma membrane
  • regulatory role for RAB5A, RAB5B, RAB5C in not only the early endocytic pathway, but also the late endocytic pathway, of membrane trafficking in coordination with PI(3)K activity
  • selective association of RAB5A and RIN1 contributes to the dominance of RAB5A in EGFR trafficking, whereas RAB5B, RAB5C may have major functions unrelated to the EGFR degradation pathway
  • role of RAB5A, RAB5B, RAB5C as endosome organizer revealing the resilience mechanisms of the endocytic system
  • RAB5A, RAB5B, RAB5C are principal components of early endosome biogenesis
  • RAB5A, RAB5B, RAB5C selectively oversee the multiple signaling and trafficking events associated with the endocytic network
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP binding
    protein
  • interacting with LRRK2 (in conjunction with its interaction with RAB5B, LRRK2 plays an important role in synaptic function by modulating the endocytosis of synaptic vesicles)
  • small GTPase protein that regulates the motility and fusion of early endosomes, interacting with LRRK2 and co-regulating synaptic vesicle endocytosis
  • cell & other
    REGULATION
    Phosphorylated by LRRK2 (LRRK2 phosphorylates RAB5B at its Thr6 residue)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    led to spindle-shaped cells that displayed reduced formation of membrane ruffles
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS