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FLASH GENE
Symbol ACVR1B contributors: - updated : 04-01-2006
HGNC name activin A receptor, type IB
HGNC id 172
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a small cysteine-rich extracellular region, with five hydrophobic amino acid residues
  • a juxtamembrane region of phosphorylation, glycine and serine rich (GS)
  • a cytoplasmic serine/threonine kinase domain
  • a functional binding site for activin
  • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme , receptor membrane serine/threonine kinase
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type 1 membrane protein
    basic FUNCTION
  • transmembrane receptor involved in protein serine / threonine kinase signaling pathway
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    transducing signals from NODAL
    a component
  • heterodimerization of alternative variants with type II receptor (forming a stable complex after ligand binding)
  • complexing with AIP1, ACVR2, ACVR1B and MADH3
  • INTERACTION
    DNA
    RNA
    small molecule
    protein activating MADH2, MADH4, FOXH1
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    in pancreatic carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS