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FLASH GENE
Symbol CDC27 contributors: mct - updated : 18-12-2013
HGNC name cell division cycle 27
HGNC id 1728
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
nine tetratricopeptide repeats (TPR )
HOMOLOGY
interspecies homolog to yeast S.cerevisiae CDC27
homolog to murine Cdc27
Homologene
FAMILY CDC27/NUC2 family
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • may be involved in controlling the timing of mitosis
  • its phosphorylation, in response to TGFB signaling can facilitate the activation of anaphase-promoting complex (APC/cyclosome)
  • CDC27 and securin participate in control of the mitotic checkpoint and survey the mitotic spindle to maintain chromosomal integrity
  • CELLULAR PROCESS cell cycle
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the APC/C) which is a large E3 ubiquitin ligase containing at least ten different, evolutionarily conserved components
  • INTERACTION
    DNA
    RNA
  • member of the anaphase promoting/cyclosome complex (APC/C) is a large E3 ubiquitin ligase containing at least ten different, evolutionarily conserved components
  • small molecule
    protein
  • RB binding
  • CDC27 directs CCND1 to alternative degradation by APC/C
  • interaction between HSF2 and the APC/C subunit CDC27 and coactivator CDC20 is enhanced by moderate heat stress, and the degradation of HSF2 is induced during the acute phase of the heat shock response
  • MCPH1 can recognize phosphorylated CDC27 via its tandem BRCT domains, and interaction between MCPH1 and CDC27 is dependent on the phosphorylation of CDC27
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • CDC27 and PTTG1 appear promising biomarkers for applications in predicting disease progression, prognostication of breast cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    potential target in anti-mitotic drug development
    ANIMAL & CELL MODELS