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FLASH GENE
Symbol TIE1 contributors: mct - updated : 07-12-2013
HGNC name tyrosine kinase with immunoglobulin and epidermal growth factor homology domains
HGNC id 11809
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three fibronectin-type III homology domains
  • thre EGF-like domains
  • two Ig-like C2-type (immunoglobulin-like) domains
  • HOMOLOGY
    Homologene
    FAMILY TYR protein kinase family, TIE subfamily
    CATEGORY enzyme , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • receptor tyrosine kinase, same class as TEK (see symbol)
  • involved in angiogenesis
  • may play a novel proinflammatory role in atherosclerosis
  • its deficiency induces endothelial-mesenchymal transition
  • endothelial cell-specific tyrosine kinase receptor, which maintains vascular integrity and regulates angiogenesis via modulating angiopoietin/TEK signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TIE1-TEK interactions are dynamic, inhibitory, and differentially modulated by ANGPT1 and ANGPT2
  • molecular balance between receptor tyrosine kinases TIE1 and TEK is dynamically controlled by VEGF and TNF and regulates angiopoietin signalling
  • expression level of TIE1 and its physical interaction with TEK defines whether ANGPT2 functions as a TEK2 agonist or antagonist, thereby determining the context-dependent differential endothelial sensitivity to ANGPT2
  • under hypoxic conditions, TIE1 is critical for reducing ANGPT1-induced TEK activity and angiogenesis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in myeloid leukemia with early chronic phase and shorter survival
    constitutional     --low  
    in serum may serve as a marker of proliferative vasculopathy in systemic sclerosis (SSc) with disease duration of >6 years
    tumoral     --low  
    endothelial-mesenchymal transition (EndMT) associated with TIE1 downregulation participates in the pathological development of stroma observed in tumours
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS