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FLASH GENE
Symbol APOBEC1 contributors: mct/npt - updated : 28-03-2018
HGNC name apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
HGNC id 604
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a mooring sequence to promote editing of an appropriably located cytidine
  • a C terminal leucine rich region
  • alpha helix
    • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Apobec1
    homolog to E.coli Cda
    intraspecies homolog to APOBEC2
    Homologene
    FAMILY
  • RNA-editing deaminase family
  • cytidine and deoxycytidylate deaminase family
    • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    text nucleo-cytoplasmic trafficking protein
    basic FUNCTION
  • responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA
  • editing HBV DNA (Gonzalez 2009)
  • act through an RNA-interacting cofactor, APOBEC1 complementation factor (ACF) (Nonaka 2009)
    • CELLULAR PROCESS protein, editing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
  • part of the apolipoprotein B mRNA editing complex
    • INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • Zn2+
    • protein
  • interacting with A1CF)
  • BAG4 binds to APOBEC1 via its N-terminal region independent of the BAG domain
  • SYNCRIP is involved in viral replication, neural morphogenesis, modulation of circadian oscillation, and the regulation of the cytidine deaminase APOBEC1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    phosphorylation of ACF (APOBEC-1 complementation factor) by PKC may be a key regulatory mechanism of APOBEC1 in rat hepatocytes (Lehmann 2007)