basic FUNCTION
| involved in nervous system development |
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may serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system |
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with NHLH1, maintain migration and survival of cells in the anterior extramural migration stream (aes) |
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NHLH2 transcriptional activity directly influences the human and rodent body weight control pathways |
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NHLH2 might function as a molecular sensor in different adult hypothalamic neurons to regulate energy balance, leading to normal body weight and reproduction |
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hypothalamic transcription factor that controls the expression of prohormone convertase 1/3, therefore having an impact on the processing of proopiomelanocortin and thus on energy homeostasis |