basic FUNCTION
| sodium-independent, high- affinity, transport of large neutral amino-acids, involved in cellular amino-acid uptake |
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AA permease-related protein which for surface expression and function requires formation of disulfide-linked heterodimers with the glycosylated heavy chain of the h4F2/CD98 surface antigen (Pfeiffer 1999) |
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playing a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina |
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with SLC7A8, functions as influx and/or efflux transport machinery displaying a greater propensity for the outward transport of large and small neutral amino acids (Omidi 2008) |
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major transporter of tyrosine in human fibroblast cells (Vumma 21008) |
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may be important to modulate thyroid hormone effects on osteoblast differentiation and on bone development and metabolism (Capelo 2009) |