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FLASH GENE
Symbol CDK11A contributors: mct/pgu - updated : 27-06-2016
HGNC name cyclin-dependent kinase 11A
HGNC id 1730
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a helicase ATP-binding domain
  • a helicase c-terminal domain
  • HOMOLOGY
    interspecies homolog to Drosophila Pitslre
    homolog to C.elegans B0495.2
    Homologene
    FAMILY
  • protein kinase superfamily
  • CMGC Ser/Thr protein kinase family
  • CDC2/CDKX subfamily
  • CATEGORY enzyme , receptor serine/threonine kinase
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • playing roles in cell apoptosis
  • a G2/M specific protein that contributed to regulation of cell cycle, transcription and apoptotic signal transduction
  • exert important functions in mitotic process, such as the regulation of bipolar spindle formation and sister chromatid cohesion
  • role of CCND3/CDK11A complex in repressing the Schwann cells proliferation and inducing its apoptosis
  • CELLULAR PROCESS cell cycle
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    text cell cycle control
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • interacting with PAK1(PAK1 may serve as a downstream effector of CDC2L2 during mitosis progression)
  • interacting with ESR1 (ESR1 was down-regulated by CDC2L2 in mammalian cells in a ligand independent manner)
  • CHEK2 kinase promotes pre-mRNA splicing via phosphorylating CDK11A(p110)
  • CDK11A is an anti-metastatic gene in ESR1-positive breast cancer and that the regulation of ITGB3 by CDK11 via the repression of ESR1 signaling may constitute part of a signaling pathway underlying breast cancer invasion
  • involved in G2/M transition and degradation of several transcription factors, CDK11A directly interacts with and phosphorylates SPDEF on serine residues, leading to subsequent ubiquitination and degradation of SPDEF through the proteasome pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in neuroblastoma
    constitutional     --low  
    caused defective chromosome congression, premature sister chromatid separation, permanent mitotic arrest and cell death
    Susceptibility to type 2 diabetes in a Han Chinese cohort
    Variant & Polymorphism SNP SNP11 strongly associated with female patients with T2D
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS