Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TFCP2 contributors: mct/ - updated : 24-12-2009
HGNC name transcription factor CP2
HGNC id 11748
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to Drosophila transcription factor Elf-1/NTF-1
intraspecies homolog to UBP1
Homologene
FAMILY
  • grh/CP2 family
  • CP2 subfamily
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text exclusively localized in the cytosol
    basic FUNCTION
  • possible trancriptional regulator of immunodeficiency virus type 1
  • recognizing several distinct binding motifs by virtue of employing different regions, thus being able to interact with and regulate many cellular partners
  • playing an important role in the regulation of erythroid genes
  • exhibiting some tissue- or stage-specific activation toward certain genes such as globin in red blood cells and interleukin-4 in T helper cells
  • critical regulator of erythroid gene expression
  • role in fibronectin expression
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • dimerizing with NFE2 to form the stage selector protein complex
  • heterodimerization with UBP1 is necessary for nuclear localization
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GSKB, APBB1 (FE65) and others involved in the inflammatory response
  • two HXPR motif-containing proteins REST and YY1 were able to bind TFCP2
  • interacting with RNF2 and PHB2 (RNF2 and PHB2 modulate the TFCP2-mediated transcriptional pathway)
  • TFCP2 is an essential transcription factor for SRY expression regulation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Alzheimer disease
    Variant & Polymorphism SNP 3'utr G>A protective effect of A allele
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS