basic FUNCTION
| putatively involved in BRCA1 regulation |
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autophagic receptor for ubiquitin-positive protein aggregates , |
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targeting SQSTM1 to sarcomeres where it interacts with MURF2 |
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functions as an autophagy receptor involved in targeting ubiquitinated proteins for degradation |
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role in bone remodeling, where loss of function leads to perturbation of SQSTM1 levels and hyperactivation of MAPK14 that favors osteoblastogenesis |
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modulates MAPK14 signaling in osteoblasts and is a regulator of osteoblast differentiation |
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play fundamental roles in the control of bone remodeling through the regulation of signaling pathways in different cell types |
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novel PB1 adapter in Th2 differentiation and asthma |
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multidomain scaffold protein with proposed roles in endocytic trafficking and selective autophagy |
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negative regulator of ligand-mediated receptor tyrosine kinases degradation |