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FLASH GENE
Symbol ATP5F1D contributors: mct - updated : 12-04-2018
HGNC name ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
HGNC id 837
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
isoforms Precursor
HOMOLOGY
Homologene
FAMILY ATPase epsilon chain family
CATEGORY enzyme , transport
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
intracellular,cytoplasm,organelle,mitochondria,matrix
intracellular,cytoplasm,organelle,membrane
basic FUNCTION
  • producing ATP from ADP in the presence of a proton gradient across the membrane
  • plays an important role in coupling proton translocation and ATP production
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text protein
    PATHWAY
    metabolism energetic
    signaling
    oxydative phosphorylation
    a component
  • constituent of mitochondrial matrix F1 segment
  • component of complex V of oxidative phosphorylation (OXPHOS)
  • INTERACTION
    DNA
    RNA
    small molecule
    ADP, ATP, Pi binding
    protein
  • association between ATP5F1D and the Aa98-113 domain of MPL (the dissociation of ATP5F1D from MPL after TPO stimulation suggests that ATP5F1D may be a new component of TPO signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ATP5F1DD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    cytosolic accumulation observed even at early stages of neurofibrillary degenerating process in Alzheimer disease
    constitutional     --low  
    in the spinal cord in ALS: decreased ATP5D levels suggest synaptic dysfunction in ALS pathogenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target potential target for therapeutic and diagnostic strategies in AD
    ANIMAL & CELL MODELS