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FLASH GENE
Symbol LAMC2 contributors: mct/npt - updated : 21-09-2015
HGNC name laminin, gamma 2
HGNC id 6493
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 21 amino acids signal peptide (2.3 kDa)
  • three laminin A/neurexin/sex hormone-binding (LNS) globular domains separated by multiple EGF-like motifs within N terminal truncated short arm
  • a long arm composed of heptad repeats typical of a cell alpha helical coiled-coil protein
  • conjugated GlycoP
    mono polymer heteromer , trimer
    isoforms Precursor a 1172 amino acids mature peptide (128.8 kDa)
    HOMOLOGY
    interspecies homolog to rattus Lamc2 (84.96 pc)
    homolog to murine Lamc2 (83.91 pc)
    Homologene
    FAMILY
  • intermediate filament family, type V
  • CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION extracellular
    text basement membrane
    basic FUNCTION
  • mediating the attachment, migration and organization of cells into tissues during embryonic development
  • plays an important role for tumour migration and shows an increased expression in areas of direct tumour/stroma interactions
  • negatively regulates the integrin beta 4 phosphorylation, probably through a syndecan-1-mediated signaling, leading to enhanced cell adhesion and suppressed cell motility
  • LAMB3, LAMC2, in conjunction with MMP7, play a key role in the progression of biliary tract cancer
  • CELLULAR PROCESS cell life, proliferation/growth
    cell communication
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • heterotrimerizing with laminin alpha 3 and beta 3 in laminin 5 (kalinein/nicein)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding heparin, nidogen 1 (NID), fibulin (FBLN1, FBLN2)
  • RSK activation of translation factor EIF4B drives abnormal increases of LAMC2 and MYC protein during neoplastic progression to squamous cell carcinoma
  • cell & other
    REGULATION
    activated by cleaved by BMP1,facilitating basement membrane assembly
    Other its expression was regulated by histone methylation as well as DNA methylation
    ASSOCIATED DISORDERS
    corresponding disease(s) EBJ1A , EBJ2A
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    expressed in non small cell lung cancer (coexpression with LAMB3)
    tumoral     --over  
    of LAMB3 and LAMC2 by promoter demethylation in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • LAMC2 is a potential prognostic markers for pancreatic ductal adenocarcinoma (PDAC)
  • Therapy target
    SystemTypeDisorderPubmed
    cancerendocrinepancreas
    LAMC2 is a potential therapeutic targets for pancreatic ductal adenocarcinoma (PDAC)
    ANIMAL & CELL MODELS