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FLASH GENE
Symbol INPP5B contributors: mct - updated : 01-10-2014
HGNC name inositol polyphosphate-5-phosphatase, 75kDa
HGNC id 6077
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal proline rich domain
  • a central 5 phosphatase domain
  • a C terminal CAAX domain
  • HOMOLOGY
    intraspecies paralog to OCRL
    Homologene
    FAMILY inositol polyphosphate 5-phophatase subfamilies
    CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text
  • is localised to the early secretory pathway including the Golgi apparatus and ER-to-Golgi intermediate compartment (ERGIC)
  • basic FUNCTION
  • involved in signal terminating reaction in the inositol signaling pathway and in regulation of Golgi vesicular trafficking
  • role for INPP5B in retrograde ERGIC-to-ER transport and imply that it has functions distinct from those of OCRL within both the secretory and endocytic pathways
  • functional overlap of OCRL and INPP5B in most cell lineages, especially in extraembryonic tissues
  • OCRL and INPP5B are differentially expressed in the human and murine eyes, and play compensatory roles in cilia development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling signal transduction
    inositol
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAB binding is required for efficient Golgi targeting of INPP5B
  • partial functional redundancy between INPP5B and OCRL for primary cilia assembly
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS