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FLASH GENE
Symbol GPX2 contributors: mct - updated : 30-01-2008
HGNC name glutathione peroxidase 2 (gastrointestinal)
HGNC id 4554
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus
basic FUNCTION
  • glutathione peroxidase involved in free radical detoxification
  • involved in transcriptional response to exogenous redox agents and catabolic pathway of activated oxygen species
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein direct target of TP63, inhibiting oxidative stress-induced apoptosis in a TP53-dependent manner
    cell & other
    REGULATION
    activated by TP63
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS