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FLASH GENE
Symbol PTS contributors: - updated : 27-12-2005
HGNC name 6-pyruvoyltetrahydropterin synthase
HGNC id 9689
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , hexamer
HOMOLOGY
Homologene
FAMILY PTPS family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
intracellular,cytoplasm,cytoskeleton
basic FUNCTION
  • 6-pyruvoyl-tetrahydrobiopterin synthase, catalyzing the second step of tetrahydrobiopterin (BH4) synthesis
  • involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • homohexamer formed of two homotrimers in a head to head fashion
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
    1 zinc ion per subunit
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PTSD
    related resource 6-Pyruvoyl-tetrahydropterin synthase deficiency
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS