protein
| BRCA1, |
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BARD1, TP53 |
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RAD54 |
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SHFM1 |
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XRCC3, RAD54L and RAD54B |
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RAD51AP1 and RAD51AP2 |
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CHEK1/CHK1 |
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interacting with the MND1-PSMC3IP heterodimer |
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interacting with OBFC2B |
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DNA helicase Srs2 |
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SFPQ |
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important function of XRCC2 is to enhance the activity of RAD51, so that the loss of XRCC2 results in a severe delay in the early response of RAD51 to DNA damage |
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assembly of RAD51 at DNA damage is strictly controlled by RAD51 mediators, including BRCA1 and BRCA2 |
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associates with RAD52, RAD54, and BRCA2 during recombinational repair |
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SFPQ association with the RAD51 protein complex is essential for homologous recombination repair of DNA damage and maintaining genome integrity |
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directly binds GEMIN2/SIP1 |
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interacting with PALB2 (RAD51 interacted with the N terminus (AAs 1–200) of PALB2 and also its C terminus (residues 853–1186) |
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interacting with BRCA2 (role of BRCA2 in catalysing the delivery of RAD51 to sites of DNA damage) |
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in cooperation with RAD54 may have a new role in DNA lesion bypass that is distinct from DNA strand invasion |
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SWI5-SFR1 directly interacts with RAD51 and plays a critical role in homologous recombination repair |
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BRCA2 interacts with RAD51 through both the BRC repeats and the C-ter |
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BRCA2 specifically binds to RAD51 via eight BRC repeat motifs and delivers RAD51 to double-stranded DNA breaks |
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has an active role in homologous recombination (HR) and DNA double-strand break (DSB) repair but does not alter the intracellular level of the RAD51 |
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CDK1 permits resection by phosphorylation of RBBP8 but also prevents RAD51 binding to the resected ends during M-phase double-strand break repair |
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RAD52 is potentially an alternative repair pathway of RAD51-mediated homologous recombination (HR) |
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MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination |
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SPIDR independently interacts with BLM and RAD51 and promotes the formation of a BLM/RAD51-containing complex of biological importance |
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interacts directly with the RAD51 paralogue complex BCDX2 and functions in parallel to the Fanconi anaemia pathway to promote efficient homologous recombination at damaged replication forks |
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ATRX stimulates RAD51-mediated DNA strand exchange and promotes branch migration of Holliday junctions |
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MEIOB appeared to be dispensable for the initial loading of recombinases but was required to maintain a proper number of RAD51 and DMC1 foci beyond the zygotene stage |
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FBXO18 binds directly to RAD51 and is able to disrupt RAD51 filaments on DNA through its ssDNA translocase function |
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AGO2 very likely functions directly in mediating RAD51 accumulation at DSBs |
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BRCA2, a key RAD51 binding partner, coordinates the activity of the central cell-cycle drivers CDKs and PLK1 to promote RAD51-mediated genome stability control |
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PSMC3IP-MND1 induces changes in the conformation of RAD51 that profoundly alter the basic properties of RAD51 |
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BRCA2 facilitates nucleation of RAD51 filaments at multiple sites on single-stranded DNA |
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FBXO18 acting as a negative regulator of RAD51 function in human cells |
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ATM is needed for later steps in HR after RAD51 nucleofilament formation |
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DMC1 and RAD51 are conserved recombinases that catalyze homologous recombination |
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CSE1L associates with RAD51 in human cells, and negatively regulates the nuclear protein level of RAD51 under normal conditions |
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TOPBP1 physically binds PLK1 and promotes PLK1 kinase-mediated phosphorylation of RAD51 at serine 14, a modification required for RAD51 recruitment to chromatin |
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BRCA2 interacts directly with both RAD51 and DMC1 (pMID: 26976601) |
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NEK1 regulates RAD51 removal to orchestrate HR and replication fork stability. |
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by specifically regulating RAD51 activity at uncoupled replication forks, MMS22L-TONSL stabilizes perturbed replication forks by promoting replication fork reversal and stimulating their HR-mediated restart |
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NEK8 is required for efficient DNA damage-induced RAD51 foci formation |
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RECQL5 removes RAD51 filaments stabilizing stalled replication forks at common fragile sites (CFSs) and hence facilitates CFS cleavage by MUS81-EME1 |
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both BRCA1 and BARD1 bind DNA and interact with RAD51, and BRCA1-BARD1 enhances the recombinase activity of RAD51 |
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suggesting a sex-specific function for the two proteins) |
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SYCP3 functions in meiotic homologous recombination biased to interhomologous chromosomes, by regulating the strand invasion activities of the RAD51 and DMC1 recombinases |
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E2F7 restricts homologous recombination through the transcriptional repression of RAD51 |
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the bromodomain of BRD9 binds acetylated K515 on ATRX and facilitates ATRX interaction with RAD51, which is essential for HR |
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BRME1 is a novel recombination factor and probably mediates DMC1/RAD51 recruitment to ssDNA or their stability on chromosomes through physical interaction with HSF2BP |
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prominent RPA1-interacting partners are the tumor suppressor protein TP53, RAD51, ATRIP and ETAA1 |