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FLASH GENE
Symbol CHRNA7 contributors: mct/npt/shn/pgu - updated : 23-01-2018
HGNC name cholinergic receptor, nicotinic, alpha 7 (neuronal)
HGNC id 1960
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a large N terminal extracellular domain
  • two agonist binding sites
  • four transmembrane segments (4TM) with the M2 domain comprising the cation-selective pore
  • conjugated Other
    mono polymer homomer , pentamer
    HOMOLOGY
    interspecies ortholog to chrna7, Danio rerio
    ortholog to Chrna7, Mus musculus
    ortholog to CHRNA7, Pan troglodytes
    ortholog to Chrna7, Rattus norvegicus
    Homologene
    FAMILY
  • ligand-gated ionic channel family
  • CATEGORY receptor , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    text present in the outer membranes of mitochondria to regulate the early apoptotic events like cytochrome c release
    basic FUNCTION
  • regulating keratinocyte chemokinesis and chemotaxis, respectively, and signaling pathways mediating these functions, having clinical implications for wound healing and control of cancer metastases
  • implicated in neuronal functions, including learning, memory, and attention
  • plays an important role in non-small cell lung cancer cell growth and tumour progression as well as in cell death
  • plays a dominant role in nicotine-induced cell signaling
  • distinct and varied spatiotemporal expression of CHRNA7 during tooth development
  • is an important mediator of cholinergic transmission during brain development
  • exhibits a pleiotropic role in the hematopoietic system that includes both the direct modulation of pro-inflammatory cell composition and later in the adult the role of modulating pro-inflammatory responses that would impact upon an individual lifelong response to inflammation and infection
  • regulates axon growth in hippocampal neurons, thereby likely contributing to synaptic formation in the developing brain
  • regulate mitochondrial permeability transition pore formation through ion-independent mechanism involving activation of intramitochondrial PI3K/AKT1 pathway and inhibition of calcium-calmodulin-dependent or SRC-kinase-dependent signaling pathways
  • is a ligand-activated ion channel that contributes to a diversity of cellular processes involved in development, neurotransmission and inflammation
  • contributes to multiple aspects of adrenal gland development and function that persist into adulthood
  • role of the CHRNA7 in schizophrenia and likely cholinergic neurotransmission involving the CHRNA7 could be involved in sensory registration processes
  • activating CHRNA7 can promote diabetic wound healing by suppressing advanced glycation end products (AGEs)-induced TNF production, which may be closely associated with the blockage of NFKB1 activation in macrophages
  • make a complex contribution to network activity and synaptic plasticity in the prelimbic cortex
  • is emerging as an important drug target for intervention in inflammation and sepsis
  • anti-inflammatory role of CHRNA in Natural killer (NK) cells
  • has many important consequences in neuronal cells, including modulation of neuronal excitability and neurotransmitter release as well as calcium flux directly impacting multiple cellular signaling pathways
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • 42-amino acid beta-amyloid peptide, Abeta(1-42) (
  • PI3K p85 subunit and Fyn (
  • PWS-IC (
  • TFAP2A plays a negative role in regulating CHRNA7 transcription
  • interaction between CHRNA7 and a G-protein pathway complex regulates neurite growth in neural cells
  • regulate the early apoptotic events like cytochrome c release
  • APP promotes translocation of CHRNA7 towards the cell surface and CHRNA7 rescues neuronal cells from APP-induced damage
  • RIC3 is a known chaperone of neuronal CHRNA7
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL15Q13 , DUP15Q13
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    may signal a compensatory response to maintain basocortical cholinergic activity during Alzheimer disease progression
    tumoral     --over  
    its expression is significantly higher in small-cell lung carcinoma (SCLC), as in carcinoid tumor
    Susceptibility to autism spectrum disorder
    Variant & Polymorphism other rare variants in autism spectrum disorder susceptibility
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    psychiatryschizophrenia 
    repression of CHRNA7 mRNA by TFAP2A might be evaluated as a potential modulatory factor in the development of pharmacological targets to treat the symptoms of schizophrenia and other mood disorders
    reproductiongenital 
    activation of CHRNA7 might be a new candidate for treatment of endometriosis
    neurologyneurodegenerativealzheimer
    activation of the CHRNA7/PI3K signaling pathway and its cross-talk with the Wnt signaling pathway might well be therapeutic targets for potential AD treatments
    ANIMAL & CELL MODELS
  • expression of CHRNA7 is significantly reduced frontal cortex from Rett syndrome and autism patients (
  • alpha7 nAChR knockout (KO) mouse is viable and has only slight visual dysfunction