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FLASH GENE
Symbol PRDX1 contributors: mct - updated : 03-11-2016
HGNC name peroxiredoxin 1
HGNC id 9352
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to murine Prdx1
Homologene
FAMILY
  • thioredoxin peroxidase family
  • peroxiredoxin protein family
  • 2-Cys Prx subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • strong cytoplasmic labeling in the basal cells of the corneal epithelial layer and the corneoscleral limbus
  • localized mainly in the nucleus of neural cells
  • basic FUNCTION
  • playing a role in elimination of peroxides generated during metabolism
  • having a function in apoptosis signal-regulating kinase 1 (MAP3K5)-mediated signaling pathway
  • have a role in both the resistance of certain cancers to therapy and quite a different role in possibly slowing the progression of neurodegenerative
  • having a function in apoptosis signal-regulating kinase 1 (MAP3K5)-mediated signaling pathway
  • peroxidase function of PRDX1 is involved in regulating RAS-induced transformation
  • pivotal regulator of GDPD5 activity, suggesting roles for coupled thiol-redox-dependent cascades in controlling neuronal differentiation in the spinal cord
  • catalyze peroxide reduction of H(2)O(2), organic hydroperoxides and peroxynitrite
  • involved in the cellular protection against oxidative stress, the modulation of intracellular signalling cascades as well as the regulation of cell proliferation and apoptosis
  • essential for preventing respiratory syncytial virus-induced oxidative damage in a subset of nuclear intermediate filament and actin binding proteins in epithelial cells
  • PRDX1-stimulated endothelial cell proliferation, migration, and differentiation in a TLR4- and VEGF-dependent manner
  • role in regulating TGFB1-induced epithelial-to-mesenchymal transition (EMT)
  • detoxifies peroxide substrates and has been implicated in numerous biological processes, including cell growth, proliferation, differentiation, apoptosis, and redox signaling
  • may perform biological functions as a RNA-binding protein, which are distinctive from known functions of PRDX1 as a reactive oxygen species scavenger
  • novel role of PRDX1 in phagocytosis of macrophage
  • orchestrates potentially redox signaling in an H&
  • 8322;O&
    8322; dose-dependent manner through the oxidation status of its peroxidatic cysteine Cys52
  • is involved in disassembly of flagella and cilia, and suggested that the abnormal expression of the cilia-related gene including PRDX1 may affect both ciliogenesis and cancerogenesis
  • site-specific acetylation of PRDX1 may change its biological role in response to environmental changes
  • involved in the control of the pericentrosomal H2O2 level that is critical for mitotic progression
  • interaction of PRDX1 with APEX1 represents a novel anti-inflammatory function of PRDX1, whereby the association safeguards APEX1 from reducing transcription factors and activating superfluous gene expression, which otherwise could trigger cancer invasion and metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text skeletal development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PSEN1 (to protects against neuronal apoptosis)
  • interacts with MAP3K5 via the thioredoxin-binding domain of MAP3K5 and this interaction is highly inducible by H2O2
  • interacts with AR and enhances its transactivation
  • binding to PTEN is essential for protecting PTEN from oxidation-induced inactivation
  • cooperates with GDPD5 to drive motor neuron differentiation, and this synergy requires PRDX1 thiol-dependent catalysis
  • regulated the expression of two E-cadherin transcriptional repressors, SNAI1, SNAI2
  • specifically coordinates MAPK14-induced signaling through regulating MAPK14 phosphatases in an H&
  • 8322;O&
    8322; dose-dependent manner
  • PRDX1, regulator of aging, is a novel PIN1 binding protein, and PIN1 is involved in regulation of PRDX1 peroxidase activity
  • APEX1 interacts with a novel partner PRDX1, a peroxidase that can also prevent oxidative damage to proteins by serving as a chaperone
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    is an important factor in esophageal squamous cancer progression and could serve as a useful prognostic marker
    tumoral     --over  
    in asbestos-related lung cancer-adenocarcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker potential use of PRDX1 as a biomarker for abdominal aortic aneurysm (AAA) evolution
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    disrupting the interaction between PRDX1 and AR may serve as a fruitful new target in the management of prostate cancer
    cancerreproductiveprostate
    novel therapeutic target for prostate carcinoma
    cancermetastases 
    regulation of EMT induction by hPrx1 may be a potential target for therapeutic strategies directed against cancer metastasis
    ANIMAL & CELL MODELS
  • Prdx1-deficient (Prdx1-/-) mice showed increased susceptibility to Mycobacterium tuberculosis