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FLASH GENE
Symbol NDUFV2 contributors: mct - updated : 01-03-2011
HGNC name NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
HGNC id 7717
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • carrying a binuclear iron-sulfure cluster
  • HOMOLOGY
    Homologene
    FAMILY
  • complex1, 24 kda subunit family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • NADH ubiquinone dehydrogenase (Q reductase), involved in transfer of electrons from NADH to the respiratory chain
  • part of a large multisubunit assembly of the mitochondrial inner membrane that channels high-energy electrons from metabolic NADH into the electron transport chain (ETC)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NDUFV2
    related resource MITOP database
    Susceptibility
  • to Parkinson disease
  • to bipolar disorder
  • Variant & Polymorphism SNP
  • rs6506640 (-342G > A) and rs906807 (86C > T) was found to be associated with bipolar disorder
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS