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FLASH GENE
Symbol RTN1 contributors: mct - updated : 04-06-2015
HGNC name reticulon 1
HGNC id 10467
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 200 amino acid C-terminal domain containing two long hydrophobic sequences
  • two transmembrane helices and the N- and C-terminal regions which are supposed in the cytosolic side of ER
  • a C-terminal reticulon homology domain containing two hydrophobic segments and a 66-amino acid hydrophilic loop
  • HOMOLOGY
    Homologene
    FAMILY reticulon family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • anchored to membranes of the endoplasmic reticulum through its carboxy-terminal regions
  • Mutant proteins lacking the first (39 residues) or second (36 residues) hydrophobic segment showed ER localization, but mutant lacking both hydrophobic segments was cytosolic
  • MANF co-localized with RTN1 in the ER
  • basic FUNCTION
  • maybe involved in neuroendocrine secretion and membrane trafficking not inhibiting axonal regeneration
  • RTN1 and RYR2 might act as functional partners in the regulation of cytosolic Ca(2+) dynamics the in neurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RYR2 is a direct binding partner of RTN1, and RTN1 and RYR2 might act as functional partners in the regulation of cytosolic Ca(2+) dynamics the in neurons
  • induces PDI redistribution in ER vesicles, and concomitantly modulates its activity by decreasing the levels of its S-nitrosylated form
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    in lung tumor cells, expression of NSP-A and most likely also NSP-C is restricted to cells with a neuroendocrine phenotype
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS