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FLASH GENE
Symbol GRP contributors: mct - updated : 31-08-2013
HGNC name gastrin-releasing peptide
HGNC id 4605
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
isoforms Precursor preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the 10 aa neuromedin C
HOMOLOGY
Homologene
FAMILY bombesin/neuromedin B/ranatensin family
CATEGORY receptor membrane
SUBCELLULAR LOCALIZATION extracellular
basic FUNCTION
  • stimulating gastrin release as well as other gastrointestinal hormones
  • GRP and GRPR have important oncogenic properties beyond their established mitogenic functions
  • GRP-containing neurons in the paraventricular nucleus may be part of the hypothalamic signaling pathway controlling food intake and energy balance
  • plays an important role in regulating tumor growth and migration
  • communicates photic phase setting signals in the SCN (suprachiasmatic nucleus) by increasing neurophysiological activity of SCN neurons
  • neuropeptide that acts through G protein coupled receptors (GPCRs) involved in signal transmission in both central and peripheral nervous systems
  • triggers neutrophil recruitment both indirectly, through macrophages, as well as directly, binding to GRPR in these cells
  • has a selective effect over neutrophils in vivo, inducing their migration through activation of GRPR
  • stimulate the proliferation and invasiveness of androgen-independent prostate carcinoma
  • could function locally in the dorsal spinal cord in addition to its roles in DRG neurons
  • GRP) is a regulatory peptide that acts through its receptor (GRPR) to regulate physiological functions in various organs
  • neuropeptide that acts through G protein coupled receptors and is involved in signal transmission in both the central and peripheral nervous systems
  • GRP and GRPR are relevant to the inflammatory response, being a potential therapeutic target several diseases are related to inflammation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS digestion
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PI3K is essential for GRP-induced neutrophil migration
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate cancer with aggressive phenotype
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS