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FLASH GENE
Symbol RHOT2 contributors: mct - updated : 11-01-2016
HGNC name ras homolog gene family, member T2
HGNC id 21169
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two GTPase domains separated by two calcium binding EF-hand motifs
  • C-terminal transmembrane domain, which confers targeting to the mitochondria
  • HOMOLOGY
    interspecies homolog to murine Arht2
    intraspecies homolog to ARHT1
    Homologene
    FAMILY
  • mitochondrial Rho GTPase family
  • Ras family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • hydrolase activity leading to intracellular signaling cascade
  • role in mitochondrial homeostasis and apoptosis
  • atypical Rho GTPases, having essential roles in mitochondrial trafficking
  • MIRO proteins that serve as a [Ca(2+)](c)-sensitive switch and bifunctional regulator for both the motility and fusion-fission dynamics of the mitochondria
  • RHOT1, RHOT2 are core components of mitochondrial transport complexes
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • GTP binding
  • Ca2+ binding
  • protein
  • interacts with the Kinesin-binding proteins, TRAK1 and TRAK2, suggesting that the Miro GTPases form a link between the mitochondria and the trafficking apparatus of the microtubules
  • MFN1 and MFN2 interact with mammalian MIRO (RHOT1/RHOT2) and Milton (TRAK1) proteins, members of the molecular complex that links mitochondria to kinesin motors
  • selective binding by TRAK1 and/or TRAK2 to different members of the kinesin transport family or to RHOT1 and RHOT2 may represent crucial regulatory points in controlling the traffic of mitochondrial cargoes in neurons
  • DISC1 associates robustly with TRAK1 which is, in turn, known to interact with the outer mitochondrial membrane proteins RHOT1/2, linking mitochondria to the kinesin motor for microtubule-based subcellular trafficking
  • DISC1 couples to the mitochondrial transport and fusion machinery via interaction with the outer mitochondrial membrane GTPase proteins RHOT1, RHOT2, the TRAK1 and TRAK2 mitochondrial trafficking adaptors, and the mitochondrial fusion proteins (mitofusins)
  • physical interaction between GBF1 and RHOT1, RHOT2, and also between the active GTP-bound form of ARF1 and RHOT1, RHOT2 (
  • cell & other
    REGULATION
    Phosphorylated by PINK1 (phosphorylation of RHOT2 activates proteasomal degradation of RHOT2 in a Parkin-dependent manner)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS