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FLASH GENE
Symbol XPO7 contributors: mct - updated : 23-05-2015
HGNC name exportin 7
HGNC id 14108
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
N terminal RanGTP binding motif
HOMOLOGY
intraspecies paralog to RANBP17
Homologene
FAMILY importin beta superfamily of nuclear transport receptors
CATEGORY receptor nuclear , transport
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleoplasm
intracellular,nuclear envelope,pore
text binding the nuclear pore complexes
basic FUNCTION
  • preventing activation of RanGTPase by RanGAP
  • nuclear exportin, playing a role in spermatogenesis as well as terminal erythroid differentiation
  • XPO7-dependent nuclear export signals differ fundamentally from the leucine-rich, XPO1-dependent ones, because basic residues are critical for XPO7 recruitment
  • involved in trafficking molecules out of the nucleus
  • XPO7 and RANBP17 are novel regulators of TCF3 protein action
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly binding to a nucleoporin implicated in translocation of transport receptors
  • STRADA facilitates nuclear export of STK11 by serving as an adaptor between STK11 and exportins XPO1 and XPO7
  • KPNB1, XPO7 and IPO8 mediate the translocation of RELA into the nucleus
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS