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FLASH GENE
Symbol KIF5C contributors: shn/npt/pgu - updated : 08-11-2015
HGNC name kinesin family member 5C
HGNC id 6325
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a kinesin motor catalytic domain
  • a GRIF-1 binding domain
  • a large globular N- terminal domain responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule)
  • a central alpha-helical coiled coil domain mediating the heavy chain dimerization
  • a phosphorylation site for CSNK2A1 mapped to AA 338 located in the non-motor domain (threonine 338, within the alpha-helical coiled-coil domain which is called the neck domain is the major phosphorylation site for CSNK2A1)
  • a small globular C-terminal domain which interacts with other proteins, C-terminal EYFP-tagged KIF5C, non-motor domain
  • mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies ortholog to Kif5c, Rattus norvegicus
    ortholog to Kif5c, Mus musculus
    ortholog to KIF5C, Pan troglodytes
    ortholog to CH211-157C24.3, Danio rerio
    intraspecies paralog to KIF5A and KIF5B
    Homologene
    FAMILY
  • kinesin-like protein family
  • CATEGORY structural protein , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • function as adaptors in the anterograde trafficking of organelles to synapses
  • maintenance of motor neurons
  • microtubule-associated force-producing protein that may play a role in organelle transport
  • motor proteins which transport specific cargoes along the microtubules
  • complex of KIF5C, KLC1 and CRMP2 is involved in transporting tubulin heterodimers and oligomers to the tip of the growing axon
  • imposes restrictions on the growth of the axon and does so at least in part by generating forces on the axonal microtubule array
  • KIF5C is a new binding partner for CSNK2A2, CSNK2A1
  • kinesin motor for apical trafficking of both raft-associated sucrase isomaltase and raft-independent neurotrophin receptor
  • is involved in the passage of apical cargo molecules to a post-Golgi endosomal compartment, where further segregation into distinct vesicle populations proceeds
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system , cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component oligomer composed of two heavy chains and two light chains
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • trafficking protein kinesin binding TRAK1, trafficking protein kinesin binding 2 (TRAK2) and kinesin light chain 3 (KLC3)
  • substrate for CSNK2A1 (phosphorylated by CSNK2A1, phosphorylation that will influence the dimerization of KIF5C)
  • kinesin light chain 1 (KlC1) and collapsin response mediator protein 2 (CRMP2)
  • interacts with adjacent microtubules in the mitotic spindle
  • endogenously bind the full-length variant of VHL (pVHL30) in primary kidney cells, and mediate its association to microtubules
  • ZFYVE27 interact with other hereditary spastic paraplegia-related proteins including myelin proteolipid protein 1 (PLP1), atlastin-1 (ATL1), REEP1, REEP5 (similar to REEP1), KIF5A, KIF5B, KIF5C
  • cell & other
  • associated with microtubules
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDCBM2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in sporadic amyotrophic lateral sclerosis, (SALS)and dependent of age
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS