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FLASH GENE
Symbol A4GALT contributors: np/ - updated : 29-09-2006
HGNC name alpha 1,4-galactosyltransferase
HGNC id 18149
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • type II membrane protein
  • a short N terminal cytoplasmic sequence
  • a transmembrane spanning segment (TM1)
  • a large catalytic extracellular domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine A4galt
    intraspecies homolog to 4GPcNAc-T(AGLUGT)
    Homologene
    FAMILY
  • alpha 1,4-glycosyltransferase family
  • CATEGORY enzyme , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    synthesis of glycosphingolipids
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PBGS
    Susceptibility
    Variant & Polymorphism SNP M183K
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS