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FLASH GENE
Symbol UTS2 contributors: mct - updated : 20-03-2013
HGNC name urotensin 2
HGNC id 12636
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • urotensin-2 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • acting as a vasoconstrictor
  • contributing to diseases including atherosclerosis, cardiac hypertrophy, pulmonary hypertension and tumour growth
  • vasoactive cyclic neuropeptide which activates the G protein-coupled receptor UTS2R, exerts various cardiovascular effects and may play a role in the pathophysiology of atherosclerosis
  • chemoattractant for UTS2R-expressing monocytes and indicate a pivotal role of the RhoA-Rho kinase signaling cascade in the chemotaxis induced by UTS2
  • having a major role in the pathophysiology of aldosterone-producing adenoma and pheochromocytoma and particularly in a subset of them that have been causally associated with primary aldosteronism
  • having a role in the paracrine interactions between the adrenal medulla and cortex
  • having a role in the pathogenesis and progression of cardiovascular disease
  • intrahepatic UTS2/UTS2R system has an important pathophysiological role in cirrhosis and portal hypertension
  • potential role in glucose homeostasis and diabetes
  • vasoactive peptide associated with vascular remodeling in different cardiovascular disorders
  • involved in the TGFB1 mediated mitogenic effect on airway smooth muscle cells
  • most potent vasoconstrictor, having both vasoconstrictor and vasodilatory actions, and both profibrotic and antiapoptotic activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • signals through a G-protein coupled receptor (GPCR) known as GPR14 or UTS2R
  • UTS2 and NOX4 stimulated FOXO3 activity and MMP2 is a target gene of FOXO3
  • FOXO3 is important for basal and UTS2-stimulated proliferation and vascular outgrowth
  • UTS2 and UCN stimulate the expression of MSTN (
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in patients with heart failure and in patients with renal diseases
    constitutional     --over  
    of TAC3 and UTS2 in the plasma of pre-eclamptic women
    Susceptibility
  • to NIDDM
  • to myocardial infarction in individuals with or without conventional coronary risk factors
  • Variant & Polymorphism other
  • S89N polymorphism is associated with the development of type 2 diabetes, via insulin sensitivity, in Japanese subjects
  • polymorphisms associated with myocardial infarction in individuals with or without conventional coronary risk factors
  • Candidate gene
    Marker
  • important marker of severity of portal hypertension in children
  • Therapy target
    SystemTypeDisorderPubmed
    miscelleaneousurinary 
    UTS2/UTS2R pathway may represent a novel therapeutical target in erectile dysfunction
    digestiveliver 
    potential therapeutic target in the chronic liver disease
    ANIMAL & CELL MODELS
  • 2DM mice showed increased Uts2/Uts2r content, in skeletal muscle