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FLASH GENE
Symbol TOM1L1 contributors: SGE/npt - updated : 26-01-2010
HGNC name target of myb1 (chicken)-like 1
HGNC id 11983
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal VHS (Vps27p/Hrs/Stam) domain
  • a GAT (GGA and Tom1) domain, both of which are also found in the GGA (Golgi-localizing, gamma-adaptin ear domain homology, ADP-ribosylation factor-binding protein) family of proteins
  • HOMOLOGY
    interspecies homolog to murine Tom1l1 (79.2pc)
    intraspecies homolog to TOM1
    Homologene
    FAMILY
  • TOM1 family
  • CATEGORY adaptor , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    text cytosolic TOM1L1 is recruited onto the plasma membrane and subsequently redistributed into the early endosome (Liu 2009)
    basic FUNCTION
  • adapter protein involved in signaling pathways, interacting with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated
  • participating in EGF-stimulated endocytosis of EGF receptor (Liu 2009)
  • may promotes FYN activation
  • involved in the FcepsilonRI signal transduction for the generation of cytokines (Zhang 2007)
  • playing a role in linking EGFR- and SFK-dependent signaling to differentiation in keratinocytes (Li 2005)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with FYN, GRB2 and PIK3R1
  • GAT domains interact with ubiquitin and TOLLIP
  • interacting with the activated EGFR bridged by Grb2 and Shc (Liu 2009)
  • cell & other
  • associates with the midbody during cytokinesis (Yanagida-Ishizaki 2008)
  • REGULATION
    Other phosphorylated upon DNA damage probably by ATM or ATR
    Tyr-phosphorylated by the Src family kinases (Liu 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
  • decreased in the hyperproliferative keratinocytes found in the seborrheic keratoses and basal cell carcinomas (Meulener 2009)
  • Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS