Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TEKT3 contributors: mct - updated : 30-11-2010
HGNC name tektin 3
HGNC id 14293
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved tektin domain
  • HOMOLOGY
    interspecies homolog to sea urchin tektin A1
    Homologene
    FAMILY
  • occludin/ELL family
  • tektin family
  • CATEGORY motor/contractile , structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    basic FUNCTION
  • cilia and centriole formation
  • microtubule-associated cytoskeletal protein expressed primarily in the male germ cell-lineage in centrioles and basal bodies and within ciliary and flagellar doublet microtubules
  • male germ cell-enriched protein that it might perform important roles in male reproductive development and physiology
  • important role in male reproductive development and physiology
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text spermatogenesis
    PATHWAY
    metabolism
    signaling
    a component
  • co-assembling with tubulins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • potential candidate genes for nonsyndromic asthenozoospermia
  • Marker
    Therapy target
    ANIMAL & CELL MODELS
  • expressed in round spermatids in mouse
  • male mice null for TEKT3 produce sperm with reduced motility (47.2p100 motility) and forward progression, and increased flagellar structural bending defects