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FLASH GENE
Symbol SRR contributors: mct - updated : 01-07-2011
HGNC name serine racemase
HGNC id 14398
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
N terminal pyridoxal phosphate attachment sequence
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm
basic FUNCTION
  • catalyzing synthesis of D serine from L serine
  • playing a role in neuronal activity and a potential biological role in the regulation of N-methyl-D-aspartate (NMDA) receptor activity in these peripheral organs as well
  • important contribution of neuronal D-serine during retinal development
  • involved in the regulation of synaptic plasticity, neural network formation, and neurodegenerative disorders
  • plays a key role in the regulation of brain functions under physiological and pathological conditions via the production of the neuromodulator D-serine
  • responsible for the synthesis of D-serine, an endogenous co-agonist for N-methyl-D-aspartate receptor-type glutamate receptors (NMDARs)
  • physiologic coagonist at NMDA receptors, having a role in NMDA receptor-mediated neurotoxicity and stroke
  • catalyzes the racemization between l- and d-serine
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    aberrant Srr function and diminished d-serine may contribute to schizophrenia pathogenesis
    constitutional     --over  
    increased expression in the hippocampus in schizophrenia (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    psychiatryschizophrenia 
    promising target for the treatment of disorders related to NMDAR dysfunction
    ANIMAL & CELL MODELS
  • mutant Srr mice displayed behaviors relevant to schizophrenia, including impairments in prepulse inhibition, sociability and spatial discrimination