basic FUNCTION
| an important adaptor during insulin signaling |
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involved in insulin pathway recruiting phosphorylated CBL to the insulin receptor and cytoskeleton reorganization |
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regulating cytoskeletal organization and signal transduction |
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involved in formation of actin stress fibers and focal adhesions |
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modulates the important role of macrophages in the induction of insulin resistance |
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may coordinate the function of dynamin with the regulation of the actin cytoskeleton during endocytosis |
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a potential role in lens fiber cell migration, adhesive interactions, polarity and maintnace of lens transparency |
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through its interaction with FLNC, provides another link between the myofibril cytoskeleton and the plasma membrane of muscle cells, and it may play a dynamic role in the regulation and maintenance of muscle structural integrity |
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involved in insulin-stimulated glucose uptake |