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FLASH GENE
Symbol SORBS1 contributors: SGE/npt/shn/pgu - updated : 20-12-2009
HGNC name sorbin and SH3 domain containing 1
HGNC id 14565
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • sorbin homologous domain
  • three SH3 domains
  • HOMOLOGY
    interspecies ortholog to Sorbs1, Rattus norvegicus
    ortholog to SORBS1, Pan troglodytes
    ortholog to Sorbs1, Mus musculus
    Homologene
    FAMILY
  • SH3P12-ArgBP2A-vinexin adaptor family
  • SoHo family of adaptor molecules
  • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text localized at cell-cell and cell-matrix adherens junctions
    basic FUNCTION
  • an important adaptor during insulin signaling
  • involved in insulin pathway recruiting phosphorylated CBL to the insulin receptor and cytoskeleton reorganization
  • regulating cytoskeletal organization and signal transduction
  • involved in formation of actin stress fibers and focal adhesions
  • modulates the important role of macrophages in the induction of insulin resistance
  • may coordinate the function of dynamin with the regulation of the actin cytoskeleton during endocytosis
  • a potential role in lens fiber cell migration, adhesive interactions, polarity and maintnace of lens transparency
  • through its interaction with FLNC, provides another link between the myofibril cytoskeleton and the plasma membrane of muscle cells, and it may play a dynamic role in the regulation and maintenance of muscle structural integrity
  • involved in insulin-stimulated glucose uptake
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    insulin signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • recruiting CBL to the insulin receptor
  • paxillin and vinculin
  • l afadin
  • c-abl oncogene 1, receptor tyrosine kinase (ABL1)
  • ataxin 7 (SCA7)
  • flotillin
  • insulinoma-associated 1 (INSM1)
  • binding to and colocalizing with the dynamin
  • Cbl proto-oncogene
  • SH2B adaptor protein 2
  • interacts with both signaling and cytoskeletal proteins
  • SH2-containing inositol polyphosphate 5-phosphatase SHIP2
  • interacting with NCK1, NCK2
  • cell & other
    REGULATION
    activated by BRL49653
    induced by during myoblast differentiation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism SNP
  • T228A significantly associated with obesity and type 2 diabetes
  • possible association with late-onset Alzheimer disease
  • Candidate gene insulin resistance,obesity
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • deletion of Sorbs1 gene in mice protects against high-fat diet (HFD)-induced insulin resistance
  • RhoGDIalpha transgenic mouse lenses revealed a marked downregulation of expression of multiple splice variants of ponsin