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FLASH GENE
Symbol SAMSN1 contributors: mct - updated : 27-08-2012
HGNC name SAM domain, SH3 domain and nuclear localisation signals, 1
HGNC id 10528
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one SRC homology 3 domain
  • one sterile alpha motif (SAM)
  • one nuclear localization signal (NLS)
  • HOMOLOGY
    interspecies ortholog to rattus Samsn1 (82.4pc)
    ortholog to murine Samsn1 (83.2pc)
    intraspecies homolog to KIAA0790 protein
    Homologene
    FAMILY
    CATEGORY adaptor , chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • may acting as a cytoplasmic adaptor to mediate a signaling pathway
  • participating in B-cell activation and differentiation
  • may be functioning as a signaling component of mast cells, possibly in the nucleus
  • potential immunoinhibitory adaptor that might be a useful target for immune suppression
  • implicated in the epigenetic control of gene expression
  • induces RAC1-dependent membrane ruffle formation and regulates cell spreading and polarization and its SH3 domain is essential for these effects
  • physiological up-regulation of SAMSN1 observed upon B cell activation functions to counteract excessive B cell spreading
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • involved the NFKB pathway
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • phosphorylated SAMSN1 directly interacts with 14-3-3 proteins via a previously unrecognized phosphorylation site
  • in the nucleus, interacts with the SAP30/HDAC1 complex and regulates the activity of HDAC1
  • actin nucleation-promoting factor cortactin is an SH3 domain-directed interaction partner of SAMSN1
  • cell & other
    REGULATION
    Other upregulation by IL4 was STAT6 dependent
    upregulated by B-cell activation signals
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in human lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS