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FLASH GENE
Symbol PLRG1 contributors: SGE - updated : 30-06-2009
HGNC name pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
HGNC id 9089
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven WD40 domains
    • HOMOLOGY
    interspecies homolog to murine Plrg1 (96.3pc)
    homolog to rattus Plrg1 (96.3pc)
    Homologene
    FAMILY
  • WD-repeat PRL1/PRL2 family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text in spliceosome complex
    basic FUNCTION
  • necessary for spliceosome assembly and for pre-mRNA splicing (Ajuh 2003)
  • critical nuclear regulator of p53-dependent cell cycle progression and apoptosis during embryonic development and adult tissue homeostasis (Kleinridders 2009)
    • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • forms a complex with Pso4/SNEV/Prp19 and CDC5L (Kleinridders 2009)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between the CDC5L protein and PLRG1 in the CDC5L complex essential for pre-mRNA splicing progression
  • interaction between HNRPM and the spliceosome proteins cell division cycle 5-like (CDC5L) and pleiotropic regulator 1 (PLRG1) that was inhibited during the heat-shock stress response
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS