Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PAPOLA contributors: - updated : 27-09-2004
HGNC name poly(A) polymerase alpha
HGNC id 14981
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a nucleotidyl transferase domain
  • a U1A interacting domain in the C terminus
  • conjugated PhosphoP
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to murine Pap
    Homologene
    FAMILY poly (A) polymerase family
    CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text the 90kDa isoform is nuclear,the 100kDa is cytoplasmic and nuclear
    basic FUNCTION
  • polynucleotide adenylyltransferase
  • adenosine addition reaction,CPSF dependent
  • required for endoribonucleolytic cleavage reaction at some poly (A) sites
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    text mRNA processing,mRNA polyadenylation
    PATHWAY
    metabolism
    signaling
    a component component of pre RNA polyadenylation complex
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein U1A protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS