Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NTN4 contributors: mct/npt - updated : 15-04-2008
HGNC name netrin 4
HGNC id 13658
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a laminin-like domain VI
  • 3.5 laminin EGF repeats
  • a netrin C domain
  • HOMOLOGY
    interspecies homolog to murine Ntn4
    Homologene
    FAMILY
  • netrin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
    intracellular,cytoplasm,organelle,lumen
    text basement membrane
    basic FUNCTION
  • acts as an antiangiogenic factor through binding to neogenin (NEO1) and recruitment of UNC5B
  • promotes neurite elongation from olfactory bulb explants and is important in neural, kidney, and vascular development
  • may improve poststroke functional recovery by enhancing blood vessel proliferation (Hoang 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • basement membrane component (present in the basement membranes of the vasculature, kidney, and ovaries)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in VEGF-stimulated endothelial cells
    constitutional       gain of function
    in the ischemic core as soon as 1 day after cerebral ischemia, with subsequent downregulation after 1 week (Hoang 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target could be a promising alternative avenue for therapeutic intervention to anti-VEGF therapies
    ANIMAL & CELL MODELS