Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MEPE contributors: mct/npt - updated : 20/12/2008
HGNC name matrix, extracellular phosphoglycoprotein with ASARM motif (bone)
HGNC id 13361
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • multiple phosphorylation sites
  • disulfide-free flexible hydrophilic structures
  • presence of the integrin-binding tripeptide, arginine-glycine-aspartate (RGD)
  • a C terminal ASARM, (DSPP/OPN/DMP1) acidic serine-aspartate rich motif
  • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Mepe
    intraspecies homolog to other bone-tooth mineral matrix phospho-glycoproteins
    Homologene
    FAMILY
  • Small Integrin Binding Ligand N-linked Glycoprotein (SIBLING) family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • involved in phosphate and bone metabolism
  • may be having a role as an early regulator of odontogenic differentiation
  • by direct interaction, decreases CHEK1 from ubiquitin-mediated proteolysis and thus protects cells from DNA damage induced killing (Liu 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text bone mineralization
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • integrin receptor(s)
  • interacting with CHEK1 (Liu 2009)
  • DSPP, MEPE, VCAN, OGN play complementary roles during odontogenesis
  • cell & other
    REGULATION
    Other downregulated by 1.25 (OH)2D3
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in oncogenic hypophosphatemic osteomalacia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS