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FLASH GENE
Symbol KCNJ14 contributors: mct/npt - updated : 20-09-2021
HGNC name potassium inwardly-rectifying channel, subfamily J, member 14
HGNC id 6260
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two membrane-spanning domains
  • an amphipatic region pore, including the P domain with the K+ channel signature
  • an ATP-binding regulatory domain
  • mono polymer homomer , tetramer
    HOMOLOGY
    interspecies homolog to rattus Rn.14528
    homolog to Drosophila Ir
    homolog to C.elegans irk-2
    Homologene
    FAMILY
  • inward rectifier-type potassium channel family
  • potassium channel subfamily J
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • in interstitial colonic cells of Cajal
  • basic FUNCTION
  • control of the excitability of brain stem motoneurons
  • KCNN2, KCNJ14, KCNK2, and KCNK6, are involved the K(+) transports, and are thought to play an important role in the maintenance of the unique ionic milieu of the inner ear fluid
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    text voltage-gated potassium channel
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for CTRCT35
    Marker
    Therapy target
    ANIMAL & CELL MODELS