protein
| IL17A can regulate the expression, proinflammatory properties, and tissue-protective functions of IL22, and indicate that the presence or absence of IL17A governs the proinflammatory versus tissue-protective properties of IL22 in a model of airway damage and inflammation |
|
IL26 is often co-expressed with IL22 by activated T cells, especially Th17 cells |
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role of GAB1 and GAB2 in IL22-mediated keratinocyte proliferation, migration, and differentiation |
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regulation of IL22RA2 is crucial to control the effects of IL22 during intestinal tissue damage and tumorigenesis |
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IL27 may suppress the production of IL22 by inducing the expression of SOCS1 in human CD4(+) T cells |
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IL22 secreted by decidual stromal cells (DSCs) and decidual natural killer (dNK) cells might promote the survival of trophoblasts and participate in the maintenance of pregnancy by binding to the IL22RA1 |
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S100A12, S100A8, S100A9 has no direct effect on cholesterol efflux in macrophages, but rather promotes the secretion of IL22, which then directly reduces cholesterol efflux in macrophages by decreasing the expression of ABCG1 |
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IL21 is an inducer of IL22 production in CD4+ T cells |
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the role of the IL22/IL22RA1 axis in cancer is complex and context-specific |
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new functions for IKZF1 in maintaining mucosal immune homeostasis by restricting IL22 production by CD4(+) T cells |
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IL22 induces IL18 expression from epithelial cells during intestinal infection |
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in the intestinal tract, IL22 activates STAT3 to promote intestinal epithelial cell (IEC) homeostasis and tissue healing |
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TYK2 protects against acute colitis in part by amplifying inflammation-induced epithelial IL22 signaling to STAT3 |
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IL22RA2 is a soluble IL22 receptor, which antagonizes IL22 activity and has genetic associations with autoimmune diseases |
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IL22 plays likely a protective role in glucose-stimulated insulin secretion (GSIS) via the down-regulation of UCP2 |
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increased expression of IL22RA1 promotes keratinocyte proliferation and pro-inflammatory cytokine production during UVB-induced skin inflammation, suggesting that UVB facilitates skin inflammation by increasing the responsiveness of keratinocytes to IL22 |
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IL22 increases intestinal epithelial permeability by upregulating CLDN2 expression through the JAK/STAT pathway, suggesting the role of IL22 in the regulation and maintenance of the intestinal epithelial barrier |
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
|  
|  
| --low
|  
|
correlate with disease activity in patients with systemic lupus erythematosus | constitutional
|  
|  
|  
| loss of function
|
deficiency of IL22 might lead to delayed colonic repair and increased intestinal inflammation thereby promoting tumor development | constitutional
|  
|  
| --over
|  
|
in giant cell arteritis, and affects viability and gene expression of arterial cells | tumoral
|  
|  
| --over
|  
|
increased occurrence of IL22 may enhance myeloma proliferation and growth, and moreover, may participate in the mechanisms of immune deregulation | |