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FLASH GENE
Symbol IL20RA contributors: mct - updated : 13-12-2012
HGNC name interleukin 20 receptor, alpha
HGNC id 6003
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , dimer
HOMOLOGY
intraspecies homolog to IL10RB
Homologene
FAMILY
  • type II cytokine receptor family
  • CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • IL20RA and IL10RB chains participate in forming the IL26 receptor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein IL20RB
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    dramatically upregulated in psoriatic skin
    Susceptibility to psoriasis
    Variant & Polymorphism SNP
  • haplotype CCG (rs1184860, rs1167846, rs1167849) is significantly associated with psoriasis
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS