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FLASH GENE
Symbol FZD3 contributors: mct - updated : 10-09-2011
HGNC name frizzled homolog 3 (Drosophila)
HGNC id 4041
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • conserved cysteine-rich WNT binding domain
  • HOMOLOGY
    interspecies homolog to murine Fzd3
    Homologene
    FAMILY Wnt receptor family
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues
  • required for the development of major fiber tracts in the rostral central nervous system
  • essential for maintenance of dividing sympathetic neuroblasts
  • acting at early developmental stages to maintain a pool of dividing sympathetic precursors,and functioning at later stages to promote innervation of final peripheral targets by postmitotic sympathetic neuron
  • WNT3A and FZD3 signalings play important roles in regulating the proliferation and differentiation of neural crest (NC) cells and various developmental stages of melanocyte precursors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor for WNT ligands
  • intreraction with VANGL2 (role for VANGL2 in the targeting or anchoring of FZD3, suggesting that novel Planar cell polarity mechanisms exist in vertebrates)
  • WNT2 interacts with both FZD3 and FZD9
  • is essential for normal development of the commissural plate and its loss-of-function causes SLIT2-dependent defects in axon midline crossing in the embryonic vertebrate forebrain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to schizophrenia
  • to methamphetamine psychosis
  • Variant & Polymorphism SNP FZD3 haplotypes showed strong associations with methamphetamine psychosis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Fz3(-/-) sympathetic neuroblasts also undergo enhanced apoptosis, which could not be rescued by eliminating the proapoptotic factor, Bax