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FLASH GENE
Symbol CHORDC1 contributors: mct - updated : 11-05-2011
HGNC name cysteine and histidine-rich domain (CHORD)-containing, zinc binding protein 1
HGNC id 14525
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a cysteine and histidine rich domain
  • two CHORD domains (I and II)
  • one CS domain (a domain shared by CHORD-containing proteins and SGT1)
  • HOMOLOGY
    interspecies homolog to CHORD containing C.elegans gene
    intraspecies homolog to melusin (ITGB1BP)
    Homologene
    FAMILY
    CATEGORY chaperone/stress , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • Hsp90-interacting protein
  • behaves like an HSP90 co-chaperone and possesses an independent molecular chaperone activity towards denatured proteins
  • potential involvement in natural protective mechanisms
  • appears to prevent both centrosome amplification and tumorigenesis
  • controls genomic stability by regulating the centrosome cycle via ROCK2
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Zn2+
    protein binds to the ATPase domain of Hsp90
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS