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FLASH GENE
Symbol CCNI contributors: mct - updated : 24-06-2016
HGNC name cyclin I
HGNC id 1595
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY cyclin family
CATEGORY regulatory
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • may have a physiological role in spermatogenesis and/or human sperm cell function--especially in capacitation and/or acrosome reaction
  • protects podocytes from apoptosis, and likely this is mediated by stabilization of CDKN1A
  • activators of CDK5, CDK5R1, and CCNI are not required for normal kidney function, but, they play pivotal coordinated roles in maintaining podocyte survival during stress states in disease
  • has a role in the regulation of cell cycle progression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CDK5 is activated by both CCNI and the noncyclin activator CDK5R1 in terminally differentiated cells such as kidney podocytes and neurons
  • interaction between Cyclin I and CDK5 was detected in cells overexpressed with both proteins
  • predominance of CCNI mediates the nuclear localization of CDK5, whereas the predominance of CDK5R1 results in a membranous localization of CDK5
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS