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FLASH GENE
Symbol ASPN contributors: mct - updated : 17-08-2007
HGNC name asporin
HGNC id 14872
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal leucine-rich repeat and cysteine domain, playing an important role in the PLAP1/asporin
  • BMP2 interaction
  • one unique stretch of aspartic acid residues
  • HOMOLOGY
    interspecies homolog to murine Aspn
    intraspecies homolog to decorin
    Homologene
    FAMILY
  • class I SLRPs (small leucine-rich repeat proteoglycan) family
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
    text extracellular matrix
    basic FUNCTION
  • involved in the mineralized matrix formation in periodontal ligament
  • suppressing TGFB-mediated expression of aggrecan (ACAN) and type II collagen (COL2A1)
  • acting as a negative regulator of chondrogenesis by inhibiting TGFB function
  • negative regulator of cytodifferentiation and mineralization probably by regulating BMP-2 activity
  • blocks chondrogenesis and inhibits TGF1-induced expression of matrix genes and the resulting chondrocyte phenotypes
  • negatively regulates chondrogenesis in articular cartilage by blocking the TGF-/receptor interaction on the cell surface and inhibiting the canonical TGF-/Smad signal
  • critical regulator of TGF- in articular cartilage and thus plays an essential role in cartilage homeostasis and OA pathogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TGFB1
  • interacting with BMP2 (inhibits BMP2-induced differentiation of periodontal ligament cells resulting from inactivation of the BMP2 signaling pathway)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to osteoarthritis in Japanese population
  • to lumbar disc degeneration (LDD)
  • Variant & Polymorphism other
  • allele D14 osteoarthritis susceptible, association of the ASPN D14 allele and knee osteoarthritis
  • allele D13 osteoarthritis protective
  • allele D14 significantly associated with LDD in Chinese and Japanese individuals
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS