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FLASH GENE
Symbol ARTN contributors: - updated : 06-01-2007
HGNC name artemin
HGNC id 727
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to murine Artn
intraspecies homolog to artemin
Homologene
FAMILY
  • glial cell-lines derived neutrophic factor family of ligand (GDNF)
  • TGF-beta superfamily
  • CATEGORY regulatory , signaling growth factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • neutrophic factor involved in stimulation of neurite outgrowth, exerting selective effects on pain sensation
  • ligand for the RET receptor and using GFR-alpha 3 as coreceptor
  • activating the GFR alpha 1 RET receptor complex
  • acting as a guidance factor that encourages sympathetic fibers to follow blood vessels as they project toward their final target tissues
  • promoting the survival of ventral midbrain dopaminergic neurons in culture and prevents their degeneration after treatment by 6 hydroxydopamine in vivo
  • exhibiting neurotrophic activity on mesencephalic dopaminergic and motor neurons
  • involved in processes subserving both the organization of the cortical region during development and the functional activity and maintenance of the mature hippocampal neurons
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS development
    text
  • neuroblast proliferation
  • neuronal development
  • PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand for GFRA3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS