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FLASH GENE
Symbol OPTC contributors: mct/npt - updated : 17/11/2008
HGNC name opticin
HGNC id 8158
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • a central domain consisting of five B-type leucine-rich repeats
  • a N terminal of four cysteine clusters
  • a C terminus with two cysteine residues
  • an additional LRR between them
  • HOMOLOGY
    interspecies homolog to murine Opticin
    intraspecies homolog to epyphycan
    homolog to osteoglycin
    Homologene
    FAMILY
  • SLRP family, clan III (small leucine reich repeat proteoglycan)
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
    text extracellular matrix, vitreous
    basic FUNCTION
  • may be playing a role in vitreoretinal adhesion and the co-localisation of opticin with type XVIII collagen/endostatin might contribute to vitreoretinal adhesion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • opticin for ternary complex with TGFBI and COL6
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • collagen fibrils and other ECM proteins
  • interacting with decorin, fibromodulin and lumican (can help protect collagen fibrils from cleavage by collagenases)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS