Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol WDR6 contributors: mct/npt - updated : 27-08-2009
HGNC name WD repeat domain 6
HGNC id 12758
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eleven WD repeats domain, clustered into two distinct groups separated by a putative transmembrane segment
  • HOMOLOGY
    interspecies homolog to Arabidosis t7b11.12
    homolog to S.cerevisiae ypl183c
    Homologene
    FAMILY
  • WD repeat protein family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text localized in cytoplasm, similar to the localization of STK11 (Xie 2007)
    basic FUNCTION
  • regulation of a wide variety of cellular function (signal transduction, transcription, proliferation)
  • implicated in the cell growth inhibitory pathway of STK11 via regulation of CDKN1B (Xie 2007)
  • may be participates in insulin/IGF-I signaling and the regulation of feeding behavior and longevity in the brain (Chiba 2009)
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • able to interact with STK11 (coexpression of WDR6 and STK11 was able to induce CDKN1B) (Xie 2007)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS