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FLASH GENE
Symbol MMP26 contributors: mct/npt - updated : 08-04-2010
HGNC name matrix metalloproteinase 26
HGNC id 14249
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide, involved in enzyme latency
  • a prodomain
  • a catalytic domain with the zinc binding site and an adjacent threonine residue
  • lacking the hinge region and hemopoxin-like (PEX) C terminal domain
  • conjugated GlycoP , MetalloP
    isoforms Precursor
    HOMOLOGY
    intraspecies homolog to macrophage metalloelastase,MMP3,MMP12
    Homologene
    FAMILY
  • stromelysin subclass of MMP family
  • peptidase M10A family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    text extracellular matrix
    basic FUNCTION
  • proteolytic enzyme in the extracellular matrix tissue remodeling events associated with tumor progression
  • MMP21, MMP26 are not only associated with cancer but may be important in connective tissue remodelling and pathobiology of various benign skin disorders
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • Zn2+
  • Ca2+
  • protein
  • cleaved gelatin, alpha-protein inhibitors, fibrinogen
  • progelatinase B (activation)
  • binding TIMPs in a 1:1 stoechiometry
  • interacting with STRAP (serine threonine receptor-associated protein (STRAP) is a further protein recruited to the MMP28 promoter and acting functionally with Sp1) (Swingler 2010)
  • HOXA10-mediated expression of MMP26 promotes embryo adhesion during the process of embryonic implantation.
  • cell & other
    REGULATION
    activated by proteinases
    induced by histone deacetylase (HDAC) inhibitors and this effect is mediated through the GT-box (Swingler 2010)
    inhibited by TIMPs and TFPI2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in Merkel cell carcinoma with larger tumors and with poor prognosis(Suomela 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS