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FLASH GENE
Symbol SH3GLB2 contributors: mct/npt - updated : 21-10-2014
HGNC name SH3-domain GRB2-like endophilin B2
HGNC id 10834
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal sequence folded into an amphipathic alpha-helix in the membrane environment, and N-BAR domain
  • a coiled coil (dimerization) domain
  • C-terminal SH3 domain flanking a variable intermediate region, and PLEC is a molecular partner of SH3GLB2 SH3 domain
    • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Spas-1
    intraspecies homolog to RING3 protein
    Homologene
    FAMILY
  • endophilin-related protein family
  • endophilin family of BAR and Src homology 3 domain-containing proteins
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • playing a regulatory role in synaptic vesicle recycling
  • functions in the perinuclear organization of intermediate filaments
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • homodimer and heterodimer with SH3GLB1
  • endophilin B2-plectin 1 complex functions as a membrane-anchoring device organizing and stabilizing the perinuclear network of vimentin filaments
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BAX apoptotic inducer
  • interacts directly with plectin 1 and controls the perinuclear vimentin network
  • physical and functional links between SH3GLB2 and vimentin
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer
    tumoral     --over  
    in prostate cancer metastases
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target potentially attractive candidate target antigen for the development of antigen-targeted immunotherapies in humans
    ANIMAL & CELL MODELS