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FLASH GENE
Symbol TRAP1 contributors: mct - updated : 26-01-2022
HGNC name TNF receptor-associated protein 1
HGNC id 16264
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mitochondrial localization sequence in the N terminus
conjugated PhosphoP
HOMOLOGY
interspecies homolog to murine Trap1 (88.5pc)
homolog to rattus Trap1 (88.5pc)
Homologene
FAMILY heat shock protein 90 (HSP90) chaperone family
CATEGORY chaperone/stress
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
intracellular,cytoplasm,organelle,mitochondria,interspace
intracellular,cytoplasm,organelle,mitochondria,matrix
intracellular,cytoplasm,organelle,membrane
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • exhibiting ATPase activity
  • might play a role in protecting mitochondria against damaging stimuli via decrease of reactive oxygen species generation
  • protecting cells from oxidative stress and apoptosis
  • mitochondrial survival factor differentially expressed in localized and metastatic prostate cancer compared with normal prostate
  • acts as a molecular chaperone to retinoblastoma protein (Rb) during cellular stress
  • controls cell cycle activity through the tumor necrosis factor pathways
  • mitochondrial chaperone with antioxidant and antiapoptotic functions, involved in multidrug resistance in colorectal carcinoma cells
  • likely reduces the hypertrophy and fibrosis induced by pressure overload through blocking TAK/P38, JNK, and AKT signaling pathways
  • is involved in the translational control of cancer cells through an attenuation of global protein synthesis
  • controls cell migration of cancer cells in metabolic stress conditions
  • TRAP1 is relevant in the control of the complex machinery that governs cell cycle progression and mitotic entry
  • molecular chaperone involved in the regulation of energetic metabolism in cancer cells
  • role of TRAP1 is to enhance or suppress oxidative phosphorylation
  • potential TRAP1 role in triggering the alternate energy metabolism in cancer cells
  • TRAP1 role in tumor metastasis, which is in addition to altered energy metabolism
  • it is involved in the assembly of the electron transport chain, and it favours the switch from oxidative phosphorylation to glycolysis
  • supports protein folding and contributes to the maintenance of mitochondrial integrity even under cellular stress
  • cellular regulator of mitochondrial bioenergetics, redox homeostasis, oxidative stress-induced cell death, apoptosis, and unfolded protein response (UPR) in the endoplasmic reticulum (ER)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP binding
    • protein
  • binding to the intracellular domain of tumor necrosis factor type 1 receptor
  • binding to RB1
  • interacting with cyclophilin D and negatively regulating mitochondrial cell death
  • Sorcin (SI) is a new TRAP1 interactor
  • a functional role of TRAP1 in maintaining mitochondrial integrity downstream of PINK1 and complex I deficits but parallel to or upstream of Parkin
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    prevented cardiac hypertrophy and fibrosis
    tumoral     --over  
    in several cancers, such as glioblastoma, colon, breast, prostate and lung cancers, often associated with drug resistance
    tumoral     --low  
    in specific tumors, such as ovarian, bladder and renal cancers, correlated with the worst prognoses and chemoresistance
    constitutional germinal mutation      
    autoinflammatory disease might be enhanced by bi-allelic mutations
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • potential of TRAP1 inhibitors as neuroprotective drugs
    • Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    targeting the TRAP1 pathway with Gamitrinibs could be explored as novel molecular therapy in patients with advanced prostate cancer
    cancer  
    targeting TRAP1 constitutes likely a new antitumor approach
    cancerendocrinethyroid
    TRAP1 inhibition may be regarded as potential strategy to target specific features of thyroid carcinoma (TC), cell proliferation and resistance to apoptosis
    ANIMAL & CELL MODELS