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FLASH GENE
Symbol LGALS8 contributors: mct - updated : 25-09-2013
HGNC name lectin, galactoside-binding, soluble, 8 (galectin 8)
HGNC id 6569
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N and C terminal carbohydrate-binding domains connected by a link peptide, N terminal contains a unique WGEI motif instead of the consensus WG-E-R/K motif (role in sugar binding)
  • two covalently linked carbohydrate recognition domains (CRDs)
  • HOMOLOGY
    interspecies ortholog to rattus Lgals8
    intraspecies homolog to LGALS4
    Homologene
    FAMILY beta galactoside binding protein family (galaptin family)
    CATEGORY secretory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    text
  • cytosolic lectin
  • basic FUNCTION
  • involved in cellular interactions and neoplastic transformation (inintegrin-like cell interaction)
  • role for LGALS8 and PDPN in supporting the connection of the lymphatic endothelium to the surrounding extracellular matrix, most likely in cooperation with other glycoproteins on the surface of lymphatic endothelial cells
  • potent platelet activator, supporting a role for this lectin in thrombosis and inflammation
  • critical role for this lectin in the regulation of capillary-tube formation and endothelial cell migration
  • essential role for LGALS8 in the regulation of angiogenesis with critical implications in tumor biology
  • novel function in activating RHO signaling in TM (trabecular meshwork) cells, function that may allow LGALS8 to participate in the regulation of aqueous outflow
  • serves potentially as a versatile receptor for vesicle-damaging pathogens
  • danger receptor LGALS8, by recruiting CALCOCO2, directs autophagy towards invading bacteria
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor-ligand relationships between CD44 and LGALS8, interactions which may affect the extent of the autoimmune inflammatory response in the synovial fluid of rheumatoid arthritis patients
  • primary target of LGALS8 must be the sugar chains on members of the integrin family, which are abundantly expressed on the surface of leucocytic cells
  • by recruiting CALCOCO2, galectin 8 activates antibacterial autophagy
  • danger receptor that senses cytosolic host glycans and recruits CALCOCO2 to restrict Salmonella proliferation
  • LGALS8 interacts with ALCAM at the surface of breast cancer cells through glycosylation-dependent mechanisms
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS