basic FUNCTION
| involved in cellular interactions and neoplastic transformation (inintegrin-like cell interaction) |
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role for LGALS8 and PDPN in supporting the connection of the lymphatic endothelium to the surrounding extracellular matrix, most likely in cooperation with other glycoproteins on the surface of lymphatic endothelial cells |
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potent platelet activator, supporting a role for this lectin in thrombosis and inflammation |
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critical role for this lectin in the regulation of capillary-tube formation and endothelial cell migration |
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essential role for LGALS8 in the regulation of angiogenesis with critical implications in tumor biology |
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novel function in activating RHO signaling in TM (trabecular meshwork) cells, function that may allow LGALS8 to participate in the regulation of aqueous outflow |
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serves potentially as a versatile receptor for vesicle-damaging pathogens |
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danger receptor LGALS8, by recruiting CALCOCO2, directs autophagy towards invading bacteria |